So... neighbors and family have had great experience with their mini-splits.
Our experience has been bad - constant freon leaks. There's a lot more hose and the freon is running through both the compressor and the head unit, so lots of fail points.
Also, we have forced air heat, so if we had done traditional, we could have just tied into the heating ducting and be done with it. Big mistake for us.
So my feeling is that if you are starting from scratch and you will use the minisplits for heating and cooling, it makes a lot of sense (assuming you're in a place where they can heat effectively). If you're adding to an existing house, I think it depends on what you have for ducting and access and how hard it will be to run ducting.