I have mixed feelings about that.
I think it's fair to say that hallucinogenic mushrooms were one of the things I used to self-medicate for depression in my late teens, early twenties. I think it might have even worked (obviously, I didn't do double blind tests on myself). And one of the benefits of having it come up during a security clearance investigation in the 1980s, is that the government already knows... so now you do too.
But one of the things that concerns me about decriminalization is that it is still typically criminal to sell, but not to buy. So you create a demand, but the supplier can go to jail.
It's like the old laws on prostitution (and possibly current - I don't know what the laws are) where prostitutes get arrested and clients mostly skate. That seems completely backwards, especially when so many of the women are coerced. Certainly, the supplier/customer power dynamic is different than in the case of, say, tobacco.
The drug violence and human trafficking problems would go away if the demand went away.