Around 2005, I just barely avoided an engine failure in a 2000 Grand Caravan due to synthetic forming a waxy film in the oil pan and it plugged the intake tube. IIRC, I noticed an odor, light smoke, and/or over-heating and drove it just a few miles directly to the shop. It was so weird the tech called me over to show me the waxy-plasticy ring that had formed around the inside of the pan and the plug they pulled out of the tube.
Since then I've been specifying conventional oil when the shop did my changes at 8k miles. But it has been 20 years and synthetics are supposedly better now about not dissolving seals and such. Around here, all of the quick-lube shops have switched to synthetic for oil changes. I'd been thinking about trying it again.