The placebo effect swings both ways.

[rcjordan]

Patients with IBS with self-perceived gluten sensitivity reacted similarly to gluten, wheat, and sham challenges

Findings suggest that expectation played a major role in symptom generation; only some of these patients could benefit from gluten or wheat restriction


Effect of gluten and wheat on symptoms and behaviours in adults with irritable bowel syndrome: a single-centre, randomised, double-blind, sham-controlled crossover trial - The Lancet Gastroenterology & Hepatology

https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00090-1/abstract