https://medicalxpress.com/news/2020-11-link-alzheimer-disease-gut-microbiota.html

Fascinating and also frustrating. We're still far from knowing the causes and effects along that chain.

I think if you are under 30, Alzheimer's is likely to be a solved problem in your lifetime. If you are between 50 and 80, most therapies will come along too late. If you're over 75, well, it's either already a problem or is coming slowly and late enough that you'll probably not suffer the worst of it. The bad cases I have known, all had major issues by age 70.

I think gingivitis or possibly other periodontal bacteria are part of the puzzle.  IIRC, other articles I've read say gingivitis was found to penetrate the supposedly impenetrable blood/brain barrier.

"found a modest link between severe gum disease and dementia, which is consistent with some previous studies."

Study links severe gum disease to raised dementia risk
https://www.medicalnewstoday.com/articles/324760

This is fascinating....

EARLY TRIAL SHOWS FLICKERING LIGHTS COULD FIGHT ALZHEIMER'S
https://www.futurity.org/flickering-lights-sound-alzheimers-disease-2575812-2

TL;DR - flickering lights with a synchronized sound pulse at 40Hz results in "entrainment," that is, pulling the brain waves into the same rhythm, which is the gamma wave frequency, which is the state in which the brain cleans up and does housekeeping.

Meanwhile, the Biogen drug shown to reduce amyloid plaque but not yet shown to reduce symptoms of Alzheimer's has FDA approval
https://www.economist.com/science-and-technology/2021/06/07/americas-wary-approval-of-an-alzheimers-drug-offers-hope-to-millions

>Biogen drug

All I can figure is that there's a payoff in there somewhere.  At $56k per patient per year, it won't take long.

>payoff ^{(rc's conspiracy theory)}

2 FDA committee members resign over Biogen Alzheimer's drug approval | Fox News
https://www.foxnews.com/health/2-fda-committee-members-resign-biogen-alzheimers-drug-approval

+

Third member of prestigious FDA panel resigns over approval of Biogen's Alzheimer's drug

https://www.cnbc.com/amp/2021/06/10/third-member-of-prestigious-fda-panel-resigns-over-approval-of-biogens-alzheimers-drug.html

Saw that...

Alzheimer Drug 'Debacle' Continues With Yet Another Resignation
https://myhughesnet.hughesnet.com/news/read/article/newser-alzheimer_drug_debacle_continues_with_yet_another-rnewsersyn

Quote from: rcjordan on June 09, 2021, 11:44:46 PM
All I can figure is that there's a payoff in there somewhere.  At $56k per patient per year, it won't take long.

The new Alzheimer's drug that could break Medicare
Patients are desperate for hope. But there are serious concerns about Biogen's new $56,000 treatment.
https://www.vox.com/policy-and-politics/22524608/new-alzheimers-drug-cost-fda-approval-biogen

^{I read somewhere that Medicare co-pay is likely to be $12k / year.}


Biogen's debated Alzheimer's drug given to first patient

https://www.foxnews.com/health/biogen-alzheimers-drug-first-patient-rhode-island-man

FDA trims use of contentious Alzheimer's drug amid backlash
https://www.pbs.org/newshour/health/fda-trims-use-of-contentious-alzheimers-drug-amid-backlash

>payoff  ^{Or at least smells like a payoff.}

US Health Agency Calls for Inquiry into Alzheimer's Drug Review
https://www.voanews.com/science-health/us-health-agency-calls-inquiry-alzheimers-drug-review

Some drugs that are already approved may be helpful for Alzheimer's. The current approval for other diseases considerably shortens the approval process (safety part is basically done and can go straight to efficacy trials)

https://www.futurity.org/alzheimers-brains-drug-targets-2593362/